The setting is the year 202X, in Kamata, Ota Ward, Tokyo, which has become one of the world's leading entertainment districts due to the opening of the Kamata Line. The area attracts huge economic benefits and is surrounded by organized crime, foreign mafias, terrorists, smugglers, prostitution rings... and the hidden agendas of political, financial, and governmental power players. A newly assigned police officer, Nonogami, stationed at the station's front police box, feels despair over the corruption of power. However, with the overwhelming violence of "Tyranno," a massive female police officer, the cases begin to be solved.